International Registry of Stem Cell Treatment Providers  ·  2026 Clinical Edition  ·  1,278 Clinics Listed Across 64 Countries  ·  1,132 Verified
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American Pain Institute

An interventional pain management clinic in Portsmouth, New Hampshire, offering spinal and joint injections, nerve procedures and a regenerative medicine programme.

⚕ Medical Disclaimer: This profile is compiled for informational purposes only and is not medical advice, a clinical endorsement, or a statement that any treatment is proven or approved. Stem cell therapies vary widely in regulatory status and evidence. Consult a qualified physician before pursuing treatment.

Overview

The American Pain Institute is a private interventional pain management clinic at 14 Manchester Square, Suite 290, in Portsmouth, New Hampshire. Its main work is conventional pain medicine: joint injections, spinal injections, radiofrequency ablation (using heat to interrupt a pain-carrying nerve) and spinal cord stimulation. A regenerative medicine programme sits alongside this as an option the site frames as an alternative to surgery.

The site states that the regenerative programme uses what it calls messenger signalling cells together with exosomes (small particles released by cells) and platelet rich plasma (PRP, concentrated from the patient's own blood). For the cell product it names a source: umbilical cord blood, which makes that component allogeneic (from a donor). The platelet component is autologous (from the patient's own body).

What distinguishes the clinic's own writing is that it argues against some of the marketing used in this sector. Its published position is that calling these cells regenerative tissue is an exaggeration often used as a marketing device, that the cells signal repair rather than regrowing tissue themselves, and that comparisons to animals regrowing limbs are myth rather than science. A reader comparing providers may find that unusual candour useful, though it remains the clinic's own framing and is reported here rather than endorsed.

Access is by referral, and the site states that most patients are seen within about two weeks and that one physician, supported by a physician assistant, sees patients at every visit. The clinic says it works with major insurers and offers what it describes as its lowest cash prices for regenerative procedures that insurance does not cover, but no figures are published.

At a Glance

Location
Portsmouth, New Hampshire, USA
Google Rating
4.5 ★ (42 reviews)

Services and Treatments Offered

  • Joint injections for arthritis and joint pain
  • Spinal injections for back and neck conditions
  • Radiofrequency ablation for nerve-related pain
  • Spinal cord stimulation
  • Regenerative medicine using cord blood-derived cells and exosomes
  • Platelet rich plasma (PRP) injections, prepared from the patient's own blood
  • Consultation and ongoing pain management

Conditions Treated

The clinic's condition list is that of a pain practice, spanning spinal, joint and nerve pain as well as pain from cancer.

Chronic back painNeck painSpinal stenosis (narrowing of the spinal canal)SciaticaNerve damage and neuropathic painJoint pain and arthritisHerniated discsFibromyalgiaHeadachesCancer-related pain

Cell Sources and Technologies

The site states that it uses what it calls messenger signalling cells sourced from umbilical cord blood, together with exosomes and platelet rich plasma prepared from the patient's own blood.

Messenger signalling cells from umbilical cord blood — donor-derived (allogeneic); the site says it regards cord blood as the most potent source compared with bone marrow, amniotic fluid, dental pulp, fat or blood vessel linings, but does not name a tissue supplier or describe donor screeningExosomes (small particles released by cells) — described alongside the cord blood product; the site does not state how they are prepared or testedPlatelet rich plasma (PRP) — concentrated from the patient's own blood (autologous)

Physicians and Clinical Team

The site states that one physician sees patients at all visits, supported by a physician assistant.

Joshua Greenspan — MD; the clinic's physician and the sole doctor patients see at every visit, according to the site, which states he has 32 years in medical practice. The site does not list his board certifications on the pages reviewed.Kevin — physician assistant; named by first name only on the site, supporting the clinic's care

Facility and Patient Experience

The clinic occupies a suite in a medical office building at 14 Manchester Square in Portsmouth, New Hampshire, and the site states it has been at that location for 13 years. It is an outpatient interventional setting where injections, radiofrequency procedures and implant-related pain treatments are carried out; stated hours are Monday to Thursday, 7.30am to 4pm.

  • Address: 14 Manchester Square, Suite 290, Portsmouth, New Hampshire 03801
  • Telephone 603-766-8500; email contact@americanpain.org
  • Hours Monday to Thursday, 7.30am to 4pm
  • The site states the clinic has been at this location for 13 years
  • Referral required; the site says most patients are scheduled within about two weeks
  • The clinic states it works with major insurers for its pain management services
  • No laboratory or tissue-bank accreditation body is named

Cost and Payment

No prices are published. The site says the practice works with major insurance and that it offers its lowest cash prices for regenerative procedures that insurance does not cover, but gives no figures, so the cost of any cell or platelet treatment would have to be quoted at consultation.

Profile compiled from information published on the clinic's own website and from the Stem Cell Directory directory record. Details may change; confirm directly with the clinic before making decisions.

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